|
|
Nicotine + NADPH + O2 <=> nicotine-1''-N-oxide + NADP+ + H2O
|
1.14.13.101
senecionine N-oxygenase
1.14.13.8
flavin-containing monooxygenase
|
–
–
|
M
|
|
BRENDA:
BS386007
MetaCyc:
RXN66-81
|
|
|
|
Nicotine + CO2 + H+ <=> 1-Methylpyrrolinium + nicotinate
|
not assigned
|
–
|
K
|
|
KEGG:
R02861
|
|
|
|
Nicotine <=> Nornicotine
|
not assigned
|
–
|
K
|
|
KEGG:
R06738
|
|
|
|
Nicotine + H2O + oxidized_pseudoazurin <=> 6-hydroxy-L-nicotine + reduced_pseudoazurin + H+
|
1.5.99.4
nicotine dehydrogenase
|
–
|
M
|
|
MetaCyc:
NICOTINE-DEHYDROGENASE-RXN
|
|
|
|
3,6-dihydronicotine + NADP+ <=> Nicotine + NADPH + H+
|
1.1.1
|
–
|
M
|
|
MetaCyc:
RXN-13060
|
|
|
|
Nicotine + acceptor <=> N-methylmyosmine + reduced_acceptor
|
1.3.99
|
–
|
M
|
|
MetaCyc:
RXN-13076
|
|
|
|
Nicotine + reduced_[NADPH-hemoprotein_reductase] + O2 <=> (S)-nornicotine + oxidized_[NADPH-hemoprotein_reductase] + H2O + formaldehyde
|
1.14.14
|
–
|
M
|
|
MetaCyc:
RXN-8248
|
|
|
|
Nicotine + H2O + acceptor <=> reduced_acceptor + (S)-nornicotine + formaldehyde
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN66-101
|
|
|
|
Nicotine + reduced_[NADPH-hemoprotein_reductase] + O2 <=> 2''-hydroxynicotine + oxidized_[NADPH-hemoprotein_reductase] + H2O
|
1.14.14.1
unspecific monooxygenase
|
–
|
M
|
|
MetaCyc:
RXN66-146
|
|
|
|
Nicotine + reduced_[NADPH-hemoprotein_reductase] + O2 <=> nicotine-Delta1''5''-iminium_ion + oxidized_[NADPH-hemoprotein_reductase] + H2O
|
1.14.19
|
–
|
M
|
|
MetaCyc:
RXN66-61
|
|
|
|
UDP-glucuronate + Nicotine <=> nicotine-glucuronide + UDP
|
2.4.1.17
glucuronosyltransferase
|
–
|
M
|
|
MetaCyc:
RXN66-83
|
|
|
|
Nicotine + reduced_flavodoxin + O2 <=> (S)-nornicotine + formaldehyde + flavin + H2O
|
1.14.14.B11
|
–
|
|
|
BRENDA:
BS427259
|
|
|
|
Nicotine + reduced_flavodoxin + O2 <=> Nornicotine + formaldehyde + flavin + H2O
|
1.14.14.B11
|
–
|
|
|
BRENDA:
BR48984
|
|
|
|
Nicotine + H2O + O2 <=> N-methylmyosmine + H2O2
|
1.5.3.5
(S)-6-hydroxynicotine oxidase
|
–
|
|
|
BRENDA:
BS440467
|
|
|
|
Nicotine + menadione + H2O <=> 6-hydroxy-L-nicotine + menadiol
|
1.5.99.4
nicotine dehydrogenase
|
–
|
|
|
BRENDA:
BS451689
|
|
|
|
Nicotine + 2,6-dichlorophenolindophenol + H2O <=> 6-hydroxy-L-nicotine + reduced_2,6-dichlorophenolindophenol
|
1.5.99.4
nicotine dehydrogenase
|
–
|
|
|
BRENDA:
BS440466
|
|
|
|
Nicotine + methylene_blue + H2O <=> 6-hydroxy-L-nicotine + reduced_methylene_blue
|
1.5.99.4
nicotine dehydrogenase
|
–
|
|
|
BRENDA:
BS451690
|
|
|
|
Nicotine + brilliant_cresyl_blue + H2O <=> 6-hydroxy-L-nicotine + reduced_brilliant_cresyl_blue
|
1.5.99.4
nicotine dehydrogenase
|
–
|
|
|
BRENDA:
BS451688
|
|
|
|
Nicotine + 4-amino-2-methylnaphthalen-1-ol + H2O <=> 6-hydroxy-L-nicotine + reduced_vitamin_K5
|
1.5.99.4
nicotine dehydrogenase
|
–
|
|
|
BRENDA:
BS451691
|
|
|
|
Nicotine + NADPH + O2 + H+ <=> Nornicotine + formaldehyde + NADP+ + H2O
|
1.14.14.B11
|
–
|
|
|
BRENDA:
BS402793
|
|
|
|
Nicotine + NADPH + H+ <=> Nornicotine + NADP+
|
1.14.14.B11
|
–
|
|
|
BRENDA:
BS442496
|
|
|
|
Nicotine + acceptor + H2O <=> 4-(methylamino)-1-(pyridin-3-yl)butan-1-one + reduced_acceptor
|
1.5.99.4
nicotine dehydrogenase
|
–
|
|
|
BRENDA:
BS424426
|
|
|
|
Nicotine + acceptor + H2O <=> 6-hydroxynicotine + reduced_acceptor
|
1.5.99.4
nicotine dehydrogenase
|
–
|
|
|
BRENDA:
BS259393
|
|
|
|
Nicotine + acceptor + H2O <=> nicotine-N-oxide + reduced_acceptor
|
1.5.99.4
nicotine dehydrogenase
|
–
|
|
|
BRENDA:
BS259400
|
|
|
|
Nicotine + acceptor + H2O <=> 6-hydroxy-L-nicotine + reduced_acceptor
|
1.5.99.4
nicotine dehydrogenase
|
–
|
|
|
BRENDA:
BR36916
|
|
|
|
Nicotine + acceptor + H2O <=> (S)-nicotine_delta1'',5''-iminium_ion + reduced_acceptor
|
1.5.99.4
nicotine dehydrogenase
|
–
|
|
|
BRENDA:
BS259401
|
|
|
|
Nicotine + acceptor + H2O <=> Nornicotine + reduced_acceptor
|
1.5.99.4
nicotine dehydrogenase
|
–
|
|
|
BRENDA:
BS259399
|
|